The Microbiota-Gut-Brain Axis Heart Shunt Part I: The French Paradox, Heart Disease and the Microbiota.

The Microbiota-Gut-Brain Axis Heart Shunt Part I: The French Paradox, Heart Disease and the Microbiota.

Obrenovich Mark; Siddiqui Bushra; McCloskey Benjamin; Reddy V Prakash

Microorganisms

2020

2020-03-30

It has been well established that a vegetarian and polyphenol-rich diet, including fruits, vegetables, teas, juices, wine, indigestible fiber and whole grains, provide health-promoting phytochemicals and phytonutrients that are beneficial for the heart and brain. What is not well-characterized is the affect these foods have when co-metabolized within our dynamic gut and its colonizing flora. The concept of a heart shunt within the microbiota-gut-brain axis underscores the close association between brain and heart health and the so-called "French paradox" offers clues for understanding neurodegenerative and cerebrovascular diseases. Moreover, oxidation-redox reactions and redox properties of so-called brain and heart-protective foods are underappreciated as to their enhanced or deleterious mechanisms of action. Focusing on prodromal stages, and common mechanisms underlying heart, cerebrovascular and neurodegenerative diseases, we may unmask and understanding the means to better treat these related diseases.

Alzheimer; blood brain barrier; Celiac disease; cerebrovascular; co-metabolism; French paradox; heart brain shunt; HMG-Co A; leaky gut; microbiota-gut-brain axis; polyphenol; red wine; redox; TMANO; TMAO; Trimethyl-Amine-N-Oxide; vascular dementia

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2076-2607 2076-2607

NEOMED College of Medicine

NEOMED Student Publications

June 2020 Update I