Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model

Title

Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model

Creator

Reed-Geaghan Erin G; Croxford Andrew L; Becher Burkhard; Landreth Gary E

Publisher

Journal of Experimental Medicine

Date

2020
2020-04

Description

Alzheimer's disease (AD) is accompanied by a robust inflammatory response mediated by plaque-associated myeloid cells of the brain. These cells exhibit altered gene expression profiles and serve as a barrier, preventing neuritic dystrophy. The origin of these cells has been controversial and is of therapeutic importance. Here, we genetically labeled different myeloid populations and unequivocally demonstrated that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia, with no contribution from circulating peripheral monocytes.

Subject

accumulation; distinct; dynamics; fate; macrophages; monocytes; pathology; reveals; system; turnover

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

URL Address

http://doi.org/10.1084/jem.20191374

Search for Full-text

NEOMED Full-text Holding (if available) - Proxy DOI: 10.1084/jem.20191374

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Pages

e20191374

Issue

4

Volume

217

ISSN

0022-1007

NEOMED College

NEOMED College of Pharmacy; NEOMED College of Graduate Studies

NEOMED Department

Department of Pharmaceutical Sciences

Update Year & Number

June 2020 Update I

Citation

Reed-Geaghan Erin G; Croxford Andrew L; Becher Burkhard; Landreth Gary E, “Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model,” NEOMED Bibliography Database, accessed September 15, 2024, https://neomed.omeka.net/items/show/11053.