Perineuronal nets and subtypes of GABAergic cells differentiate auditory and multisensory nuclei in the intercollicular area of the midbrain.

Title

Perineuronal nets and subtypes of GABAergic cells differentiate auditory and multisensory nuclei in the intercollicular area of the midbrain.

Creator

Beebe Nichole L; Noftz William A; Schofield Brett R

Publisher

The Journal of comparative neurology

Date

2020
2020-04-17

Description

The intercollicular region, which lies between the inferior and superior colliculi in the midbrain, contains neurons that respond to auditory, visual, and somatosensory stimuli. Golgi studies have been used to parse this region into three distinct nuclei: the intercollicular tegmentum (ICt), the rostral pole of the inferior colliculus (ICrp), and the nucleus of the brachium of the IC (NBIC). Few reports have focused on these nuclei, especially the ICt and the ICrp, possibly due to lack of a marker that distinguishes these areas and is compatible with modern methods. Here, we found that staining for GABAergic cells and perineuronal nets differentiates these intercollicular nuclei in guinea pigs. Further, we found that the proportions of four subtypes of GABAergic cells differentiate intercollicular nuclei from each other and from adjacent inferior collicular subdivisions. Our results support earlier studies that suggest distinct morphology and functions for intercollicular nuclei, and provide staining methods that differentiate intercollicular nuclei and are compatible with most modern techniques. We hope that this will help future studies to further characterize the intercollicular region.

Subject

ab_10807945; ab_141607; ab_2278725; ab_2336066; ab_2336132; ab_2336874; ab_2336875; ab_2336881; ab_2534012; ab_2535710; ab_2665454; ab_2735091; ascending projections; descending projections; dorsal column nuclei; efferent connections; external nucleus; extracellular-matrix; Guinea pigs; inferior colliculus; intercollicular tegmentum; lateral lemniscus; medial geniculate-body; nucleus of the brachium of the inferior colliculus; nucleus of the brachium of the inferior colliculus; rostral pole of the inferior colliculus; rrid; RRID: AB_10807945; RRID: AB_141607; RRID: AB_2278725; RRID: AB_2336066; RRID: AB_2336132; RRID: AB_2336874; RRID: AB_2336875; RRID: AB_2336881; RRID: AB_2534012; RRID: AB_2535710; RRID: AB_2665454; RRID: AB_2735091; RRID: SCR_001775; scr_001775; superior colliculus; VGLUT2; VGLUT2

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

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ISSN

1096-9861 0021-9967

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Anatomy & Neurobiology

Update Year & Number

June 2020 Update II

Citation

Beebe Nichole L; Noftz William A; Schofield Brett R, “Perineuronal nets and subtypes of GABAergic cells differentiate auditory and multisensory nuclei in the intercollicular area of the midbrain.,” NEOMED Bibliography Database, accessed September 28, 2021, https://neomed.omeka.net/items/show/11074.

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