Animal Models of Tinnitus: A Review.

Animal Models of Tinnitus: A Review.

Galazyuk Alexander; Brozoski Thomas J

Otolaryngologic clinics of North America

2020

2020-04-20

Animal models have significantly contributed to understanding the pathophysiology of chronic subjective tinnitus. They are useful because they control etiology, which in humans is heterogeneous; employ random group assignment; and often use methods not permissible in human studies. Animal models can be broadly categorized as either operant or reflexive, based on methodology. Operant methods use variants of established psychophysical procedures to reveal what an animal hears. Reflexive methods do the same using elicited behavior, for example, the acoustic startle reflex. All methods contrast the absence of sound and presence of sound, because tinnitus cannot by definition be perceived as silence.

Acoustic startle reflex; Animal models; Operant behavioral methods; Psychophysics; Tinnitus

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journalArticle

1557-8259 0030-6665

NEOMED College of Medicine

Department of Anatomy & Neurobiology

June 2020 Update II