Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting
Title
Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting
Creator
Ahmad Nashrah; Ansari Mohammad Y; Bano Shabana; Haqqi Tariq M
Publisher
International immunopharmacology
Date
2020
2020-05-22
Description
Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1beta (IL-1beta) induced expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in primary human OA chondrocytes and cartilage explants culture under pathological conditions and explored the associated signaling pathways. We pretreated chondrocytes or explants with Imperatorin (50 muM) followed by
Subject
Imperatorin; inflammation; iNOS; Osteoarthritis; Oxidative-stress; Plant-derived-polyphenol
Identifier
Rights
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Format
journalArticle
URL Address
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Pages
106612
Volume
85
ISSN
1878-1705 1567-5769
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Update Year & Number
June 2020 Update II
Citation
Ahmad Nashrah; Ansari Mohammad Y; Bano Shabana; Haqqi Tariq M, “Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting,” NEOMED Bibliography Database, accessed February 17, 2025, https://neomed.omeka.net/items/show/11104.