Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting

Title

Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting

Creator

Ahmad Nashrah; Ansari Mohammad Y; Bano Shabana; Haqqi Tariq M

Publisher

International immunopharmacology

Date

2020
2020-05-22

Description

Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1beta (IL-1beta) induced expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in primary human OA chondrocytes and cartilage explants culture under pathological conditions and explored the associated signaling pathways. We pretreated chondrocytes or explants with Imperatorin (50 muM) followed by

Subject

Imperatorin; inflammation; iNOS; Osteoarthritis; Oxidative-stress; Plant-derived-polyphenol

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

URL Address

http://doi.org/10.1016/j.intimp.2020.106612

Search for Full-text

NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.intimp.2020.106612

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Pages

106612

Volume

85

ISSN

1878-1705 1567-5769

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Anatomy & Neurobiology

Update Year & Number

June 2020 Update II

Citation

Ahmad Nashrah; Ansari Mohammad Y; Bano Shabana; Haqqi Tariq M, “Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting,” NEOMED Bibliography Database, accessed April 25, 2024, https://neomed.omeka.net/items/show/11104.