The effect of preterm birth, recurrent laryngeal nerve lesion, and postnatal maturation on hyoid and thyroid movements, and their coordination in infant feeding.

Title

The effect of preterm birth, recurrent laryngeal nerve lesion, and postnatal maturation on hyoid and thyroid movements, and their coordination in infant feeding.

Creator

Mayerl Christopher J; Catchpole Emily A; Edmonds Chloe E; Gould Francois D H; McGrattan Katlyn E; Bond Laura E; Stricklen Bethany M; German Rebecca Z

Publisher

Journal of biomechanics

Date

2020
2020-05-22

Description

Movements of the hyoid and thyroid are critical for feeding. These structures are often assumed to move in synchrony, despite evidence that neurologically compromised populations exhibit altered kinematics. Preterm infants are widely considered to be a neurologically compromised population and often experience feeding difficulties, yet measuring performance, and how performance matures in pediatric populations is challenging. Feeding problems are often compounded by complications arising from surgical procedures performed to ensure the survival of preterm infants, such as damage to the recurrent laryngeal nerve (RLN) during patent ductus arteriosus correction surgery. Here, we used a validated infant pig model for infant feeding to test how preterm birth, postnatal maturation, and RLN lesion interact to impact hyoid and thyroid excursion and their coordination. We filmed infant pigs when feeding using videofluorscopy at seven days old (1-2 months human equivalent) and 17 days old (6-9 months human equivalent) and tracked movements of the hyoid and thyroid on both days. We found that preterm birth impacted the coordination between hyoid and thyroid movements, but not their actual excursion. In contrast, excursion of the two structures increased with postnatal age in term and preterm pigs. RLN lesion decreased thyroid excursion, and primarily impacted hyoid movements by increasing variation in hyoid excursion. This work demonstrates that RLN lesion and preterm birth have distinct, but pervasive effects on feeding performance in infants, and suggest that interventions targeted towards reducing dysphagia should be prescribed based off the etiology driving dysphagia, rather than the prognosis of dysphagia.

Subject

dysphagia; Feeding; Kinematics; Neonate; Swallowing

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

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Pages

109786

Volume

105

ISSN

1873-2380 0021-9290

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Anatomy & Neurobiology
NEOMED Postdoc Publications
NEOMED Student Publications

Update Year & Number

June 2020 Update II

Citation

Mayerl Christopher J; Catchpole Emily A; Edmonds Chloe E; Gould Francois D H; McGrattan Katlyn E; Bond Laura E; Stricklen Bethany M; German Rebecca Z, “The effect of preterm birth, recurrent laryngeal nerve lesion, and postnatal maturation on hyoid and thyroid movements, and their coordination in infant feeding.,” NEOMED Bibliography Database, accessed December 5, 2021, https://neomed.omeka.net/items/show/11105.

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