The role of miR-150 regulates bone cell differentiation and function.

Title

The role of miR-150 regulates bone cell differentiation and function.

Creator

Moussa FM; Cook Bryson P; Sondag GR; DeSanto M; Obri MS; McDermott SE; Safadi FF

Publisher

Bone

Date

2020
2020-06

Description

BACKGROUND: mir-RNAs play a role in regulating bone homeostasis. In this study we assessed the functional role of mir-RNA 150 in bone homeostasis. We also assess the effects of miR-150 deficiency on osteoblast and osteoclast differentiation and function using in vivo and in vitro approaches. METHODS: Wild type (WT) (C57BL/6J) and miR-150 KO mice were compared for a variety of parameters. Micro-CT imaging was conducted to quantify trabecular bone mass inferior to the distal growth plate of the femur. Von Kossa staining was performed for osteoblast culture mineralization.

Subject

Histomorphometry; Micro-CT; miRNA-150; Osteoactivin/GPNMB; Osteoblast; Osteoclast

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

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Pages

115470

NEOMED College

NEOMED College of Medicine
NEOMED College of Medicine Student

NEOMED Department

Department of Anatomy & Neurobiology
NEOMED Student Publications

Update Year & Number

July 2020 List

Citation

Moussa FM; Cook Bryson P; Sondag GR; DeSanto M; Obri MS; McDermott SE; Safadi FF, “The role of miR-150 regulates bone cell differentiation and function.,” NEOMED Bibliography Database, accessed June 24, 2021, https://neomed.omeka.net/items/show/11157.

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