The role of miR-150 regulates bone cell differentiation and function.
Title
The role of miR-150 regulates bone cell differentiation and function.
Creator
Moussa FM; Cook Bryson P; Sondag GR; DeSanto M; Obri MS; McDermott SE; Safadi FF
Publisher
Bone
Date
2020
2020-06
Description
BACKGROUND: mir-RNAs play a role in regulating bone homeostasis. In this study we assessed the functional role of mir-RNA 150 in bone homeostasis. We also assess the effects of miR-150 deficiency on osteoblast and osteoclast differentiation and function using in vivo and in vitro approaches. METHODS: Wild type (WT) (C57BL/6J) and miR-150 KO mice were compared for a variety of parameters. Micro-CT imaging was conducted to quantify trabecular bone mass inferior to the distal growth plate of the femur. Von Kossa staining was performed for osteoblast culture mineralization.
Subject
Histomorphometry; Micro-CT; miRNA-150; Osteoactivin/GPNMB; Osteoblast; Osteoclast
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
journalArticle
URL Address
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Pages
115470
NEOMED College
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Department
Department of Anatomy & Neurobiology
NEOMED Student Publications
Update Year & Number
July 2020 List
Citation
Moussa FM; Cook Bryson P; Sondag GR; DeSanto M; Obri MS; McDermott SE; Safadi FF, “The role of miR-150 regulates bone cell differentiation and function.,” NEOMED Bibliography Database, accessed April 19, 2024, https://neomed.omeka.net/items/show/11157.