Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols.
Title
Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols.
Creator
Ansari MY; Ahmad N; Haqqi TM
Publisher
Biomedicine & Pharmacotherapy
Date
2020
2020-07-03
Description
Osteoarthritis (OA) is the most prevalent joint degenerative disease leading to irreversible structural and functional changes in the joint and is a major cause of disability and reduced life expectancy in ageing population. Despite the high prevalence of OA, there is no disease modifying drug available for the management of OA. Oxidative stress, a result of an imbalance between the production of reactive oxygen species (ROS) and their clearance by antioxidant defense system, is high in OA cartilage and is a major cause of chronic inflammation. Inflammatory mediators, such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are highly upregulated in OA joints and induce ROS production and expression of matrix degrading proteases leading to cartilage extracellular matrix degradation and joint dysfunction. ROS and inflammation are interdependent, each being the target of other and represent ideal target/s for the treatment of OA. Plant polyphenols possess potent antioxidant and anti-inflammatory properties and can inhibit ROS production and inflammation in chondrocytes, cartilage explants and in animal models of OA. The aim of this review is to discuss the chondroprotective effects of polyphenols and modulation of different molecular pathways associated with OA pathogenesis and limitations and future prospects of polyphenols in OA treatment.
Subject
Chondrocytes; Osteoarthritis; Inflammation; Polyphenols; Nrf2; Redox
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
journalArticle
URL Address
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Pages
5-28
Volume
129
ISSN
1950-6007 0753-3322
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Update Year & Number
August 2020 List
Citation
Ansari MY; Ahmad N; Haqqi TM, “Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols.,” NEOMED Bibliography Database, accessed March 18, 2024, https://neomed.omeka.net/items/show/11239.