Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols.

Title

Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols.

Creator

Ansari MY; Ahmad N; Haqqi TM

Publisher

Biomedicine & Pharmacotherapy

Date

2020
2020-07-03

Description

Osteoarthritis (OA) is the most prevalent joint degenerative disease leading to irreversible structural and functional changes in the joint and is a major cause of disability and reduced life expectancy in ageing population. Despite the high prevalence of OA, there is no disease modifying drug available for the management of OA. Oxidative stress, a result of an imbalance between the production of reactive oxygen species (ROS) and their clearance by antioxidant defense system, is high in OA cartilage and is a major cause of chronic inflammation. Inflammatory mediators, such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are highly upregulated in OA joints and induce ROS production and expression of matrix degrading proteases leading to cartilage extracellular matrix degradation and joint dysfunction. ROS and inflammation are interdependent, each being the target of other and represent ideal target/s for the treatment of OA. Plant polyphenols possess potent antioxidant and anti-inflammatory properties and can inhibit ROS production and inflammation in chondrocytes, cartilage explants and in animal models of OA. The aim of this review is to discuss the chondroprotective effects of polyphenols and modulation of different molecular pathways associated with OA pathogenesis and limitations and future prospects of polyphenols in OA treatment.

Subject

Chondrocytes; Osteoarthritis; Inflammation; Polyphenols; Nrf2; Redox

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Pages

5-28

Volume

129

ISSN

1950-6007 0753-3322

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Anatomy & Neurobiology

Update Year & Number

August 2020 List

Citation

Ansari MY; Ahmad N; Haqqi TM, “Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols.,” NEOMED Bibliography Database, accessed October 21, 2021, https://neomed.omeka.net/items/show/11239.

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