Evaluation of anticoagulation practice with new-onset atrial fibrillation in patients with sepsis and septic shock in medical intensive care unit: A retrospective observational cohort study.

Evaluation of anticoagulation practice with new-onset atrial fibrillation in patients with sepsis and septic shock in medical intensive care unit: A retrospective observational cohort study.

Arunachalam K;Kalyan SA;Jha K;Thakur L;Pond K

Cureus

2020

2020-08-25

Objective To investigate the anticoagulation practice in patients presenting with new-onset atrial fibrillation (NOAF) during sepsis and septic shock with one-year follow-up since discharge and to evaluate factors associated with the development of NOAF. Methods A retrospective observational cohort study was conducted using chart review in patients diagnosed with sepsis and septic shock.  Results There was a total of 1132 patients diagnosed with sepsis and septic shock over a one-year period. Thirty-two patients were found to have NOAF in the setting of sepsis. Of this, eight (25%) patients were anticoagulated with warfarin and 14 (44%) patients were not anticoagulated during discharge. At one-year follow-up post-discharge, nine (29%) patients continued on warfarin and 16 (52%) patients remained not anticoagulated. Conclusion We found that the majority of patients who developed NOAF did not get anticoagulated at the time of discharge. A similar trend followed after one year of follow-up. Since proper treatment guidelines are not in place, these patients are at high risk for recurrent atrial fibrillation, stroke, transient ischemic attack, and death. (Copyright © 2020, Arunachalam et al.)

severe sepsis; septic shock; atrial fibrillation; critical care; anticoagulation

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journalArticle

e10026

8

12

2168-8184

NEOMED College of Medicine

Department of Internal Medicine

September 2020 List