Renal manifestations of tuberous sclerosis complex.

Title

Renal manifestations of tuberous sclerosis complex.

Creator

Nair N;Chakraborty R;Mahajan Z;Sharma A;Sethi SK;Raina R

Publisher

Journal Of Kidney Cancer And VHL

Date

2020
2020-08-27

Description

Tuberous sclerosis complex (TSC) is a genetic condition caused by a mutation in either the TSC1 or TSC2 gene. Disruption of either of these genes leads to impaired production of hamartin or tuberin proteins, leading to the manifestation of skin lesions, tumors, and seizures. TSC can manifest in multiple organ systems with the cutaneous and renal systems being the most commonly affected. These manifestations can secondarily lead to the development of hypertension, chronic kidney disease, and neurocognitive declines. The renal pathologies most commonly seen in TSC are angiomyolipoma, renal cysts, and less commonly, oncocytomas. In this review, we highlight the current understanding on the renal manifestations of TSC along with current diagnosis and treatment guidelines. (Copyright: Nair N et al.)

Subject

angiomyolipoma; autosomal polycystic kidney disease; renal cystic disease; tuberous sclerosis; Von Hippel–Lindau disease

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Pages

5-19

Issue

3

Volume

7

ISSN

2203-5826

NEOMED College

NEOMED College of Graduate Studies
NEOMED College of Medicine

NEOMED Department

Department of Internal Medicine
NEOMED Student Publications

Update Year & Number

September 2020 List

Affiliated Hospital

Cleveland Clinic Akron General Hospital

Citation

Nair N;Chakraborty R;Mahajan Z;Sharma A;Sethi SK;Raina R, “Renal manifestations of tuberous sclerosis complex.,” NEOMED Bibliography Database, accessed January 24, 2021, https://neomed.omeka.net/items/show/11263.

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