Topical lambda-cyhalothrin in reducing eye oscillations in a canine model of infantile nystagmus syndrome.

Title

Topical lambda-cyhalothrin in reducing eye oscillations in a canine model of infantile nystagmus syndrome.

Creator

Hertle RW;Dell'Osso LF;Jacobs JB;Yang D;Dumire J;Evano-Chapman M

Publisher

Indian Journal Of Ophthalmology

Date

2020
2020-10

Description

Purpose: To determine the ocular and systemic safety of using topical Lambda-Cyhalothrin (LCL) in a canine model of infantile nystagmus syndrome (INS). The rationale for this proposal is based on a case study of a patient whose INS improved after inadvertent ocular exposure to a pyrethroid pesticide containing LCL.; Methods: After in-vitro safety testing and IUCAC approval, we studied increasing concentrations of topical LCL drops (0.002% to 0.07%) in canines with a purposely bred defect in the RPE65 gene resulting in both retinal degeneration and INS. We collected data on ocular and systemic effects and performed eye-movement recordings (EMR).; Results: At the 0.07% concentration dose of LCL, there was minimal, reversible, conjunctival hyperemia. There was no other ocular or systemic toxicity. At the 0.06% dose, there was a visible decrease in the INS and EMR showed a 153%-240% increase in the nystagmus acuity function and a 30%-70% decrease in amplitude across gaze. There was also a 40%-60% decrease in intraocular pressure while on the drop in both eyes.; Conclusion: This animal study suggests this new pharmacological agent has potential for topical treatment of both INS and diseases with raised intraocular pressure. Further, this new treatment approach confirms the importance of extraocular muscle proprioception in ocular motor diseases and their treatment.

Subject

infantile nystagmus; Canine nystagmus; eye-drop treatment

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

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Pages

2190-2195

Issue

10

Volume

68

ISSN

1998-3689

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of General Surgery

Update Year & Number

September 2020 List

Affiliated Hospital

Akron Children's Hospital

Citation

Hertle RW;Dell'Osso LF;Jacobs JB;Yang D;Dumire J;Evano-Chapman M, “Topical lambda-cyhalothrin in reducing eye oscillations in a canine model of infantile nystagmus syndrome.,” NEOMED Bibliography Database, accessed January 17, 2021, https://neomed.omeka.net/items/show/11268.

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