Topical lambda-cyhalothrin in reducing eye oscillations in a canine model of infantile nystagmus syndrome.
Title
Topical lambda-cyhalothrin in reducing eye oscillations in a canine model of infantile nystagmus syndrome.
Creator
Hertle RW;Dell'Osso LF;Jacobs JB;Yang D;Dumire J;Evano-Chapman M
Publisher
Indian Journal Of Ophthalmology
Date
2020
2020-10
Description
Purpose: To determine the ocular and systemic safety of using topical Lambda-Cyhalothrin (LCL) in a canine model of infantile nystagmus syndrome (INS). The rationale for this proposal is based on a case study of a patient whose INS improved after inadvertent ocular exposure to a pyrethroid pesticide containing LCL.; Methods: After in-vitro safety testing and IUCAC approval, we studied increasing concentrations of topical LCL drops (0.002% to 0.07%) in canines with a purposely bred defect in the RPE65 gene resulting in both retinal degeneration and INS. We collected data on ocular and systemic effects and performed eye-movement recordings (EMR).; Results: At the 0.07% concentration dose of LCL, there was minimal, reversible, conjunctival hyperemia. There was no other ocular or systemic toxicity. At the 0.06% dose, there was a visible decrease in the INS and EMR showed a 153%-240% increase in the nystagmus acuity function and a 30%-70% decrease in amplitude across gaze. There was also a 40%-60% decrease in intraocular pressure while on the drop in both eyes.; Conclusion: This animal study suggests this new pharmacological agent has potential for topical treatment of both INS and diseases with raised intraocular pressure. Further, this new treatment approach confirms the importance of extraocular muscle proprioception in ocular motor diseases and their treatment.
Subject
infantile nystagmus; Canine nystagmus; eye-drop treatment
Identifier
Rights
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Format
journalArticle
URL Address
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Pages
2190-2195
Issue
10
Volume
68
ISSN
1998-3689
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of General Surgery
Update Year & Number
September 2020 List
Affiliated Hospital
Akron Children's Hospital
Citation
Hertle RW;Dell'Osso LF;Jacobs JB;Yang D;Dumire J;Evano-Chapman M, “Topical lambda-cyhalothrin in reducing eye oscillations in a canine model of infantile nystagmus syndrome.,” NEOMED Bibliography Database, accessed April 25, 2024, https://neomed.omeka.net/items/show/11268.