Transplant radical nephrectomy and transplant radical nephroureterectomy for renal cancer: Postoperative and survival outcomes.

Transplant radical nephrectomy and transplant radical nephroureterectomy for renal cancer: Postoperative and survival outcomes.

Nabavizadeh R;Noorali AA;Makhani SS;Hong G;Holzman S;Patil DH;Kim FY;Tso PL;Turgeon NA;Ogan K;Master Viraj A

Annals of Transplantation

2020

2020-10-23

BACKGROUND The treatment of complex tumors in non-functioning renal transplants requiring surgical extirpation is challenging. Here, we report the largest series of patients who underwent transplant radical nephrectomy for renal cell carcinoma (RCC) and transplant radical nephroureterectomy for urothelial cell carcinoma (UCC) in their transplanted kidneys. MATERIAL AND METHODS From 2004 to 2018, 10 patients underwent transplant radical nephrectomy (7 patients) and nephroureterectomy (3 patients). Retrospective analyses, in terms of complications, oncological recurrence, and survival, of peri-operative and long-term outcomes, were performed. RESULTS Out of the 10 patients, 7 had RCC and 3 had UCC. No intraoperative mortality occurred. Three patients presented with Clavien-Dindo grade IIIa or greater within 30 days of surgery. Two patients died within 60 days of surgery, both due to vascular events: one due to myocardial infarction and one due to stroke. Two other patients died: one after 2.9 years, due to myocardial infarction, and the other after 6 years, due to unknown reasons. At the 7-year follow-up, there was a 60% overall survival rate. For all patients, average survival post-nephrectomy was approximately 4.5 years, including the 6 living patients and 4 deceased patients. Importantly, there was no observed cancer recurrence. CONCLUSIONS This study reports outcomes of the largest series of transplant radical nephrectomy and nephroureterectomy for malignancies of renal allografts. In the optimized setting, extirpative surgeries appear safe, with favorable long-term oncological and survival outcomes.

Survival Analysis; Nephrectomy; Kidney Neoplasms

journalArticle

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

e925865

25

2329-0358 1425-9524 1425-9524

NEOMED College of Medicine Student

NEOMED Student Publications

October 2020 List