Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes.
Title
Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes.
Creator
Casey BM; Rice MM; Landon MB; Varner MW; Reddy UM; Wapner RJ; Rouse DJ; Biggio JR; Thorp JM; Chien EK; Saade GR; Peaceman AM; Blackwell SC; Van Dorsten JP
Publisher
American Journal of Perinatology
Date
2020
2020-04
Description
OBJECTIVE: The main purpose of this article is to evaluate whether identification and treatment of women with mild gestational diabetes mellitus (GDM) during pregnancy affects subsequent maternal body mass index (BMI), anthropometry, metabolic syndrome, and risk of diabetes. STUDY DESIGN: This is a follow-up study of women who participated in a randomized controlled treatment trial for mild GDM. Women were enrolled between 5 and 10 years after their index pregnancy. Participants underwent blood pressure, height, weight, and anthropometric measurements by trained nursing personnel using a standardized approach. A nurse-assisted questionnaire regarding screening and treatment of diabetes or hypercholesterolemia, diet, and physical activity was completed. Laboratory evaluation included fasting serum glucose, fasting insulin, oral glucose tolerance test, and a lipid panel. Subsequent diabetes, metabolic syndrome, obesity, and adiposity in those diagnosed with mild GDM and randomized to nutritional counseling and medical therapy (treated) were compared with those who underwent routine pregnancy management (untreated). Multivariable analyses were performed adjusting for race/ethnicity and years between randomization and follow-up visit. RESULTS: Four-hundred fifty-seven women with mild GDM during the index pregnancy were included in this analysis (243 treated; 214 untreated) and evaluated at a median 7 years after their index pregnancy. Baseline and follow-up characteristics were similar between treatment groups. Frequency of diabetes (9.2 vs. 8.5%, p =0.80), metabolic syndrome (32.2 vs. 34.3%, p =0.63), as well as adjusted mean values of homeostasis model assessment for insulin resistance (2.5 vs. 2.3, p =0.11) and BMI (29.4 vs. 29.1 kg/m(2), p =0.67) were also not different. CONCLUSION: Identification and treatment of women with mild GDM during pregnancy had no discernible impact on subsequent diabetes, metabolic syndrome, or obesity 7 years after delivery.
Subject
Humans; Pregnancy; Adult; Female; Blood Glucose/analysis; Surveys and Questionnaires; Follow-Up Studies; Multivariate Analysis; Insulin Resistance; Diabetes Mellitus/prevention & control; Diabetes Gestational/diagnosis/therapy; Metabolic Syndrome/prevention & control; Obesity/prevention & control
Identifier
Rights
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Format
journalArticle
URL Address
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Pages
475-482
Issue
5
Volume
37
ISSN
1098-8785 0735-1631 0735-1631
Update Year & Number
Hospital List
Citation
Casey BM; Rice MM; Landon MB; Varner MW; Reddy UM; Wapner RJ; Rouse DJ; Biggio JR; Thorp JM; Chien EK; Saade GR; Peaceman AM; Blackwell SC; Van Dorsten JP, “Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes.,” NEOMED Bibliography Database, accessed April 25, 2024, https://neomed.omeka.net/items/show/11453.