A method for evaluating breast cancer screening strategies using screen-preventable loss of life.

Title

A method for evaluating breast cancer screening strategies using screen-preventable loss of life.

Creator

Carter KJ; Castro F; Morcos RN

Publisher

Plos One

Date

2020
1905-07

Description

The objective of this study is to describe how screen-preventable loss of life (screen-PLL) can be used to analyze the distribution of life savings with mammographic screening. The determination of screen-PLL with mammography is possible using a natural history model of breast cancer that simulates clinical and pathologic events of this disease. This investigation uses a Monte Carlo Markov model with data from the Surveillance, Epidemiology, and End Results Program; American Cancer Society; and National Vital Statistics System. Populations of one million women per screening strategy are simulated over a lifetime with mammographic screening based on current guidelines of the American Cancer Society (ACS), United States Preventive Services Task Force (USPSTF), triennial screening from age 50-70, and no screening. Screen-PLL curves are generated and show guideline performance over a lifetime. The screen-PLL curve with no screening is determined by tumor discovery through clinical awareness and has the highest values of screen-PLL. The ACS and USPSTF strategies demonstrate screen-PLL curves favoring the elderly. The curve for triennial screening is more uniform than the ACS or USPSTF curves but could be improved by adding screen(s) at either end of the 50-70 age range. This study introduces the use of screen-PLL as a tool to improve the understanding of screening guidelines and allowing a more balanced allocation of life savings across an aging population. The method presented shows how screen-PLL can be used to analyze and potentially improve breast cancer screening guidelines.

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

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Pages

e0243113

Issue

12

Volume

15

ISSN

1932-6203 1932-6203

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Pathology
Department of Family & Community Medicine
NEOMED Student Publications

Update Year & Number

December 2020 List

Affiliated Hospital

Mercy Health St Elizabeth Youngstown Hospital

Citation

Carter KJ; Castro F; Morcos RN, “A method for evaluating breast cancer screening strategies using screen-preventable loss of life.,” NEOMED Bibliography Database, accessed May 23, 2024, https://neomed.omeka.net/items/show/11463.