Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.

Title

Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.

Creator

Goel N; Peng K; Lu Y

Publisher

Frontiers In Neural Circuits

Date

2020
1905-07

Description

The ability of humans and animals to localize the source of a sound in a complex acoustic environment facilitates communication and survival. Two cues are used for sound localization at horizontal planes, interaural time and level differences (ITD and ILD), which are analyzed by distinct neural circuits in the brainstem. Here, we review the studies on metabotropic glutamate receptor (mGluR)-mediated neuromodulation of both intrinsic and synaptic properties of brainstem neurons in these circuits. Both mammalian and avian animal models have been used, with each having their advantages that are not present in the other. For the mammalian model, we discuss mGluR neuromodulation in the ILD circuit, with an emphasis on the recent discovery of differential modulation of synaptic transmission of different transmitter release modes. For the avian model, we focus on reviewing mGluR neuromodulation in the ITD pathway, with an emphasis on tonotopic distribution and synaptic plasticity of mGluR modulation in coincidence detector neurons. Future works are proposed to further investigate the functions and mechanisms of mGluRs in the sound localization circuits.

Subject

mGluR; neuromodulation; sound localization; ILD; mGluR; ILD; ITD; neuromodulation; sound localization; ILD; ITD; mGluR; neuromodulation; sound localization; ITD

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

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Pages

599600

Volume

14

ISSN

1662-5110 1662-5110

NEOMED College

NEOMED College of Medicine

NEOMED Department

NEOMED Student Publications
NEOMED Postdoc Publicatons
Department of Anatomy & Neurobiology

Update Year & Number

December 2020 List

Citation

Goel N; Peng K; Lu Y, “Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.,” NEOMED Bibliography Database, accessed May 28, 2024, https://neomed.omeka.net/items/show/11469.