Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.
Title
Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.
Creator
Goel N; Peng K; Lu Y
Publisher
Frontiers In Neural Circuits
Date
2020
1905-07
Description
The ability of humans and animals to localize the source of a sound in a complex acoustic environment facilitates communication and survival. Two cues are used for sound localization at horizontal planes, interaural time and level differences (ITD and ILD), which are analyzed by distinct neural circuits in the brainstem. Here, we review the studies on metabotropic glutamate receptor (mGluR)-mediated neuromodulation of both intrinsic and synaptic properties of brainstem neurons in these circuits. Both mammalian and avian animal models have been used, with each having their advantages that are not present in the other. For the mammalian model, we discuss mGluR neuromodulation in the ILD circuit, with an emphasis on the recent discovery of differential modulation of synaptic transmission of different transmitter release modes. For the avian model, we focus on reviewing mGluR neuromodulation in the ITD pathway, with an emphasis on tonotopic distribution and synaptic plasticity of mGluR modulation in coincidence detector neurons. Future works are proposed to further investigate the functions and mechanisms of mGluRs in the sound localization circuits.
Subject
mGluR; neuromodulation; sound localization; ILD; mGluR; ILD; ITD; neuromodulation; sound localization; ILD; ITD; mGluR; neuromodulation; sound localization; ITD
Identifier
Rights
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Format
journalArticle
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Pages
599600
Volume
14
ISSN
1662-5110 1662-5110
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NEOMED College of Medicine
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Department of Anatomy & Neurobiology
Update Year & Number
December 2020 List
Citation
Goel N; Peng K; Lu Y, “Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.,” NEOMED Bibliography Database, accessed April 24, 2024, https://neomed.omeka.net/items/show/11469.