Pathophysiology of aspiration in a unilateral SLN lesion model using quantitative analysis of VFSS.

Title

Pathophysiology of aspiration in a unilateral SLN lesion model using quantitative analysis of VFSS.

Creator

Stevens M; Mayerl CJ; Bond L; German RZ; Barkmeier-Kraemer JM

Publisher

International Journal of Pediatric Otorhinolaryngology

Date

2021
2021-01

Description

OBJECTIVE: The purpose of this study was to elucidate the pathophysiology of aspiration in previously studied female infant piglets after a unilateral superior laryngeal nerve (uSLN) lesion. METHODS: Videofluoroscopic swallow studies (VFSS) were acquired from 15 female piglets ages 2-3 weeks (9 with uSLN lesion and 6 controls). VFSS were analyzed at 30 frames/second sampling rate. Quantitative measures were conducted and compared between groups using published methodologies for VFSS assessment in adult and infant humans. Measures included the: 1) number of lingual-palatal contacts (LPC) (i.e. pre-swallow), 2) total pharyngeal transit time (TPT), 3) offset of swallow (offP), as well as onset of: 4) pharyngeal stage (onP), 5) pharyngoesophageal segment opening (oPES), 6) maximum PES opening (maxPES), 7) airway closure onset (oAC), and 8) maximum airway closure (maxAC). Measures 5-7 were determined relative to onP. Bolus residue was rated by severity (0 (none) to 3 (severe)). A gamma regression was used to compare continuous measures between lesioned and control groups. RESULTS: The number of LPC (p = .006), TPT (p = .023) and timing of maxAC (p = .041) were significantly greater in the uSLN lesion than the control group. CONCLUSIONS: Outcomes of this study replicated prior published findings and elucidated that piglets with right uSLN lesions exhibited delayed maxAC. Noteworthy was the use of clinically relevant quantitative videofluoroscopic measures in piglets for comparison to future studies in human pediatric populations.

Subject

Pathophysiology; Dysphagia; Superior laryngeal nerve; Videofluoroscopy; Swallow

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

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Pages

110518

Volume

140

ISSN

1872-8464 0165-5876

NEOMED College

NEOMED College of Medicine

NEOMED Department

Professor of Anatomy & Neurobiology

Update Year & Number

January 2021 List

Citation

Stevens M; Mayerl CJ; Bond L; German RZ; Barkmeier-Kraemer JM, “Pathophysiology of aspiration in a unilateral SLN lesion model using quantitative analysis of VFSS.,” NEOMED Bibliography Database, accessed August 18, 2022, https://neomed.omeka.net/items/show/11515.

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