Expanded Analysis of 20 Pneumococcal Serotypes Associated With Radiographically Confirmed Community-Acquired Pneumonia in Hospitalized US Adults.

Title

Expanded Analysis of 20 Pneumococcal Serotypes Associated With Radiographically Confirmed Community-Acquired Pneumonia in Hospitalized US Adults.

Creator

Isturiz R; Grant L; Gray S; Alexander-Parrish R; Jiang Qin; Jodar L; Peyrani P; Ford KD; Pride MW; Self Wesley H; Counselman F; Volturo G; Ostrosky-Zeichner L; Wunderink RG; Sherwin R; Overcash JS; File T; Ramirez J

Publisher

Clinical Infectious Diseases

Date

2021
2021-05-13

Description

Background: Streptococcus pneumoniae is a causative agent of community-acquired pneumonia (CAP). The 13-valent pneumococcal conjugate vaccine (PCV13) has significantly decreased the burden of PCV13-serotype pneumococcal disease; however, disease due to nonvaccine serotypes remains substantial. A recent study documented the persistence of PCV13 serotypes among US adults hospitalized with radiographically confirmed CAP. The current analysis used a recently developed urinary antigen detection (UAD) assay (UAD2) to extend these results to additional serotypes included in an investigational PCV20 vaccine.; Methods: This prospective study enrolled adults aged ≥18 years hospitalized with radiographically confirmed CAP between October 2013-September 2016. Presence of S pneumoniae was determined by blood and respiratory sample culture, BinaxNOW® urine testing, and UAD. In addition to Quellung on cultured isolates when available, serotypes were identified from urine specimens using UAD1 for PCV13 serotypes and UAD2 for 7 PCV20-unique serotypes (8, 10A, 11A, 12F, 15B, 22F, and 33F) and 4 additional serotypes (2, 9N, 17F, and 20).; Results: Among 12,055 subjects with radiographically confirmed CAP, 1482 were positive for S pneumoniae. PCV13 and PCV20-unique serotypes were associated with 37.7% (n=559) and 27.0% (n=400) of cases, respectively; 288 subjects were exclusively diagnosed as positive for S pneumoniae by UAD2. Demographic and clinical disease characteristics were similar between subjects with CAP caused by PCV13 and PCV20-unique serotypes.; Conclusions: The current analysis using UAD2 identified a sizeable proportion of hospitalized adult CAP associated with PCV20-unique serotypes. PCV20 may therefore address the burden of CAP caused by the additional serotypes present in the vaccine. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)

Subject

pneumonia; adult; 20-valent pneumococcal conjugate vaccine; serotypes; urinary antigen detection

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

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ISSN

1537-6591

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Internal Medicine

Update Year & Number

May 2021 List

Citation

Isturiz R; Grant L; Gray S; Alexander-Parrish R; Jiang Qin; Jodar L; Peyrani P; Ford KD; Pride MW; Self Wesley H; Counselman F; Volturo G; Ostrosky-Zeichner L; Wunderink RG; Sherwin R; Overcash JS; File T; Ramirez J, “Expanded Analysis of 20 Pneumococcal Serotypes Associated With Radiographically Confirmed Community-Acquired Pneumonia in Hospitalized US Adults.,” NEOMED Bibliography Database, accessed August 17, 2022, https://neomed.omeka.net/items/show/11675.

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