Managing Complex Perianal Fistulizing Disease.

Title

Managing Complex Perianal Fistulizing Disease.

Creator

Pedersen KE; Lightner AL

Publisher

Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A

Date

2021
2021-07-27

Description

Perianal disease is a particularly morbid phenotype of Crohn's disease, affecting up to one third of patients, with a significantly diminished quality of life. Conventional medical therapy and surgical interventions have limited efficacy. Medical treatment options achieve long-term durable remission in only a third of patients. Therefore, most patients undergo an operation, leaving them with a chronic seton or at risk of incontinence with multiple interventions. Mesenchymal stem cell therapy is an emerging therapy without risk of incontinence and improved efficacy as compared with conventional therapy. Laser therapy is another new intervention. Unfortunately, up to 40% of patients still require a stoma related to perianal fistulizing disease.

Subject

Crohn's disease; MANAGEMENT; QUALITY-OF-LIFE; cell therapy; ileostomy; perianal fistula; proctectomy; ANAL FISTULA; CLINICAL-TRIAL; DOUBLE-BLIND; FECAL DIVERSION; IN-ANO; REFRACTORY CROHNS-DISEASE; STEM-CELLS; SURGICAL-TREATMENT

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

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ISSN

1557-9034

NEOMED Department

NEOMED Student Publications

Update Year & Number

August 2021 List

Citation

Pedersen KE; Lightner AL, “Managing Complex Perianal Fistulizing Disease.,” NEOMED Bibliography Database, accessed November 26, 2021, https://neomed.omeka.net/items/show/11766.

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