Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers.

Title

Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers.

Creator

Tan PPS; Hall D; Chilian WM; Chia YC; Mohd ZS; Lim HM; Kumar DN; Ching SM; Low TY; Noh MFM; Pung Y-F

Publisher

American Journal Of Physiology. Heart And Circulatory Physiology

Date

2021
2021-04-01

Description

MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their ability to withstand harsh external conditions, exosomal miRNAs possess enormous potential as noninvasive disease biomarkers for, notably hypertension, whereby exosomal miRNAs have been implicated in its pathophysiological processes. More importantly, alterations in the microenvironment as a result of disease progression can induce active and selective loading of miRNAs into exosomes. In this paper, we first review the mechanisms of miRNA loading into exosomes, followed by the roles of exosomal miRNAs in the development of hypertension, and the potentials of exosomal miRNAs as biomarkers in comparison with other free circulating miRNAs. Finally, challenges and future research surrounding exosomal miRNAs will also be discussed. This review will aid in the understanding of noninvasive biomarkers for the early diagnosis of hypertension and for probing therapeutic efficacy.

Format

Journal Article

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Integrative Medical Sciences

Update Year & Number

Jan to Aug list 2021

Citation

Tan PPS; Hall D; Chilian WM; Chia YC; Mohd ZS; Lim HM; Kumar DN; Ching SM; Low TY; Noh MFM; Pung Y-F, “Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers.,” NEOMED Bibliography Database, accessed June 14, 2024, https://neomed.omeka.net/items/show/11842.