Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease.

Title

Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease.

Creator

Xu Y; Zhu Y; Hu S; Pan X; Bawa FC; Wang HH; Wang DQ; Yin L; Zhang Y

Publisher

Molecular Metabolism

Date

2021
2021-05-15

Description

Hepatic miR-34a expression is elevated in diet-induced or genetically obese mice and patients with non-alcoholic steatohepatitis (NASH), yet hepatocyte miR-34a's role in the progression of non-alcoholic fatty liver disease (NAFLD) from non-alcoholic fatty liver (NAFL) to NASH remains to be elucidated.

Subject

Mice overexpressing or deficient in hepatocyte miR-34a and control mice were fed a diet enriched in fats, cholesterol, and fructose (HFCF) to induce NASH. C57BL/6 mice with NASH were treated with an miR-34a inhibitor or a scramble control oligo. The effect of miR-34a on the development, progression, and reversal of NAFLD was determined.

Rights

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Format

Journal Article

URL Address

http://doi.org/10.1016/j.molmet.2021.101244

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Integrative Medical Sciences

Update Year & Number

Jan to Aug list 2021

Citation

Xu Y; Zhu Y; Hu S; Pan X; Bawa FC; Wang HH; Wang DQ; Yin L; Zhang Y, “Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease.,” NEOMED Bibliography Database, accessed May 12, 2025, https://neomed.omeka.net/items/show/11854.