Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease.
Title
Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease.
Creator
Xu Y; Zhu Y; Hu S; Pan X; Bawa FC; Wang HH; Wang DQ; Yin L; Zhang Y
Publisher
Molecular Metabolism
Date
2021
2021-05-15
Description
Hepatic miR-34a expression is elevated in diet-induced or genetically obese mice and patients with non-alcoholic steatohepatitis (NASH), yet hepatocyte miR-34a's role in the progression of non-alcoholic fatty liver disease (NAFLD) from non-alcoholic fatty liver (NAFL) to NASH remains to be elucidated.
Subject
Mice overexpressing or deficient in hepatocyte miR-34a and control mice were fed a diet enriched in fats, cholesterol, and fructose (HFCF) to induce NASH. C57BL/6 mice with NASH were treated with an miR-34a inhibitor or a scramble control oligo. The effect of miR-34a on the development, progression, and reversal of NAFLD was determined.
Identifier
Rights
Elsevier has partnered with Copyright Clearance Center's RightsLink service to offer a variety of options for reusing this content.
Format
Journal Article
URL Address
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Update Year & Number
Jan to Aug list 2021
Citation
Xu Y; Zhu Y; Hu S; Pan X; Bawa FC; Wang HH; Wang DQ; Yin L; Zhang Y, “Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease.,” NEOMED Bibliography Database, accessed December 11, 2023, https://neomed.omeka.net/items/show/11854.