Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease

Title

Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease

Creator

Casali BT; Reed-Geaghan EG

Publisher

Cells

Date

2021
2021-04-20

Description

Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that populate the brain parenchyma during development. During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic plasticity, in addition to their primary role as immune sentinels. In aging and neurodegenerative diseases generally, and Alzheimer’s disease (AD) specifically, microglial function is altered in ways that significantly diverge from their homeostatic state, inducing a more detrimental inflammatory environment. In this review, we discuss the receptors, signaling, regulation and gene expression patterns of microglia that mediate their phenotype and function contributing to the inflammatory milieu of the AD brain, as well as strategies that target microglia to ameliorate the onset, progression and symptoms of AD.

Format

Journal Article

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Pharmaceutical Sciences

Update Year & Number

Jan to Aug list 2021

Citation

Casali BT; Reed-Geaghan EG, “Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease,” NEOMED Bibliography Database, accessed April 21, 2024, https://neomed.omeka.net/items/show/11874.