Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.

Title

Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.

Creator

Ohanyan V;Raph SM;Dwenger MM;Hu X;Pucci T;Mack GD;Moore IJB;Chilian WM;Bhatnagar A;Nystoriak MA

Publisher

Circulation Research

Date

2021
2021-03-19

Description

Voltage-gated potassium (Kv) channels in vascular smooth muscle are essential for coupling myocardial blood flow (MBF) with the metabolic demand of the heart. These channels consist of a transmembrane pore domain that associates with auxiliary Kvβ (voltage-gated potassium channel β)1 and Kvβ2 proteins, which differentially regulate Kv function in excitable cells. Nonetheless, the physiological role of Kvβ proteins in regulating vascular tone and metabolic hyperemia in the heart remains unknown.

Subject

To test the hypothesis that Kvβ proteins confer oxygen sensitivity to vascular tone and are required for regulating blood flow in the heart.

Rights

2021 American Heart Association, Inc

Format

Journal Article

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Integrative Medical Sciences

Update Year & Number

Jan to Aug list 2021

Citation

Ohanyan V;Raph SM;Dwenger MM;Hu X;Pucci T;Mack GD;Moore IJB;Chilian WM;Bhatnagar A;Nystoriak MA, “Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.,” NEOMED Bibliography Database, accessed May 18, 2024, https://neomed.omeka.net/items/show/11878.