Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.
Title
Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.
Creator
Ohanyan V;Raph SM;Dwenger MM;Hu X;Pucci T;Mack GD;Moore IJB;Chilian WM;Bhatnagar A;Nystoriak MA
Publisher
Circulation Research
Date
2021
2021-03-19
Description
Voltage-gated potassium (Kv) channels in vascular smooth muscle are essential for coupling myocardial blood flow (MBF) with the metabolic demand of the heart. These channels consist of a transmembrane pore domain that associates with auxiliary Kvβ (voltage-gated potassium channel β)1 and Kvβ2 proteins, which differentially regulate Kv function in excitable cells. Nonetheless, the physiological role of Kvβ proteins in regulating vascular tone and metabolic hyperemia in the heart remains unknown.
Subject
To test the hypothesis that Kvβ proteins confer oxygen sensitivity to vascular tone and are required for regulating blood flow in the heart.
Identifier
Rights
2021 American Heart Association, Inc
Format
Journal Article
URL Address
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Update Year & Number
Jan to Aug list 2021
Citation
Ohanyan V;Raph SM;Dwenger MM;Hu X;Pucci T;Mack GD;Moore IJB;Chilian WM;Bhatnagar A;Nystoriak MA, “Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.,” NEOMED Bibliography Database, accessed April 24, 2024, https://neomed.omeka.net/items/show/11878.