Pathophysiology of aspiration in a unilateral SLN lesion model using quantitative analysis of VFSS.

Pathophysiology of aspiration in a unilateral SLN lesion model using quantitative analysis of VFSS.

Stevens M; Mayerl CJ; Bond L; German RZ; Barkmeier-Kraemer JM

International Journal of Pediatric Otorhinolaryngology

2020

2020-12-10

The purpose of this study was to elucidate the pathophysiology of aspiration in previously studied female infant piglets after a unilateral superior laryngeal nerve (uSLN) lesion.

Videofluoroscopic swallow studies (VFSS) were acquired from 15 female piglets ages 2–3 weeks (9 with uSLN lesion and 6 controls). VFSS were analyzed at 30 frames/second sampling rate. Quantitative measures were conducted and compared between groups using published methodologies for VFSS assessment in adult and infant humans. Measures included the: 1) number of lingual-palatal contacts (LPC) (i.e. pre-swallow), 2) total pharyngeal transit time (TPT), 3) offset of swallow (offP), as well as onset of: 4) pharyngeal stage (onP), 5) pharyngoesophageal segment opening (oPES), 6) maximum PES opening (maxPES), 7) airway closure onset (oAC), and 8) maximum airway closure (maxAC). Measures 5–7 were determined relative to onP. Bolus residue was rated by severity (0 (none) to 3 (severe)). A gamma regression was used to compare continuous measures between lesioned and control groups.

© 2020 Elsevier B.V. All rights reserved.

Journal Article

NEOMED College of Medicine

Department of Anatomy & Neurobiology

Jan to Aug list 2021