Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis
Title
Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis
Creator
Hope C Ball
Andrew L Alejo
Trinity K Samson
Amanda M Alejo
Fayez F Safadi
Date
2022
Description
The aim of this review is to provide an updated review of the epigenetic factors involved in the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint disease characterized by chronic inflammation, ectopic bone formation within the joint, and physical and proteolytic cartilage degradation which result in chronic pain and loss of mobility. At present, no disease-modifying therapeutics exist for the prevention or treatment of the disease. Research has identified several OA risk factors including mechanical stressors, physical activity, obesity, traumatic joint injury, genetic predisposition, and age. Recently, there has been increased interest in identifying epigenetic factors involved in the pathogenesis of OA. In this review, we detail several of these epigenetic modifications with known functions in the onset and progression of the disease. We also review current therapeutics targeting aberrant epigenetic regulation as potential options for preventive or therapeutic treatment.
Source
Life (Basel)
. 2022 Apr 14;12(4):582. doi: 10.3390/life12040582.
. 2022 Apr 14;12(4):582. doi: 10.3390/life12040582.
Language
English
URL
https://doi.org/10.3390/life12040582
Citation
Hope C Ball et al., “Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis,” NEOMED Bibliography Database, accessed April 25, 2024, https://neomed.omeka.net/items/show/11986.