Brønsted Acid Catalyzed Intramolecular Friedel-Crafts Addition of Tertiary Allylic Alcohols to Indoles

Title

Brønsted Acid Catalyzed Intramolecular Friedel-Crafts Addition of Tertiary Allylic Alcohols to Indoles

Creator

Wakefield, Bryan H
Barnes, Romie
Brown, Traeannah
Jones, Ashley M
Knotts, Victoria A
Martinetti, Christina

Date

2022

Description

An intermolecular Friedel-Crafts alkylation of indole and tertiary allylic alcohols has been developed. The allylic alcohols were synthesized using a two-step procedure, then exposure of these alcohols to diphenyl phosphate facilitated the desired annulation reaction. This reaction tolerated a variety of indole substitutions to yield 1H,2H,3H,4H-pyrido[1,2-a]indoles.

Source

Journal of the South Carolina Academy of Science. Spring2022, Vol. 20 Issue 1, p6-9. 9p.

Language

English

Tags

Citation

Wakefield, Bryan H et al., “Brønsted Acid Catalyzed Intramolecular Friedel-Crafts Addition of Tertiary Allylic Alcohols to Indoles,” NEOMED Bibliography Database, accessed March 29, 2024, https://neomed.omeka.net/items/show/12217.