Efficacy of intrathecal morphine administration in pediatric patients undergoing selective dorsal rhizotomy
Title
Efficacy of intrathecal morphine administration in pediatric patients undergoing selective dorsal rhizotomy
Creator
Jared Pennington
Shawnelle Contini
Miraides Brown
Nupur Goel
Tsulee Chen
Date
2023
Description
Purpose: The purpose of this study was to evaluate the effectiveness of intrathecal morphine following selective dorsal rhizotomy in pediatric patients previously diagnosed with cerebral palsy.
Methods: This was a retrospective, cohort analysis over the course of four years. The analysis consisted of a treatment group which received intrathecal morphine (5 mcg/kg) injection and a control group that did not receive the injection prior to dural closure. All patients underwent multilevel laminectomies for selective dorsal rhizotomy at Akron Children's Hospital. The effectiveness of the treatment was measured by total dose of hydromorphone administered on patient-controlled analgesia (PCA), number of days on oral narcotics, and cumulative dose of oral narcotic.
Results: Of the analyzed 15 pediatric patients, seven patients received intrathecal morphine injection while the other eight did not receive the treatment prior to dural closure. There was a difference of 1135 mcg in total PCA dose between the study group (3243 mcg) and the control group (4378 mcg). The total PCA dose based on weight was lower in the study group (163 mcg/kg) than in the control group (171 mcg/kg).
Conclusion: Based on these findings, the administration of intrathecal morphine clinically reduces the opiate need in the first 96 hours post-operatively.
Methods: This was a retrospective, cohort analysis over the course of four years. The analysis consisted of a treatment group which received intrathecal morphine (5 mcg/kg) injection and a control group that did not receive the injection prior to dural closure. All patients underwent multilevel laminectomies for selective dorsal rhizotomy at Akron Children's Hospital. The effectiveness of the treatment was measured by total dose of hydromorphone administered on patient-controlled analgesia (PCA), number of days on oral narcotics, and cumulative dose of oral narcotic.
Results: Of the analyzed 15 pediatric patients, seven patients received intrathecal morphine injection while the other eight did not receive the treatment prior to dural closure. There was a difference of 1135 mcg in total PCA dose between the study group (3243 mcg) and the control group (4378 mcg). The total PCA dose based on weight was lower in the study group (163 mcg/kg) than in the control group (171 mcg/kg).
Conclusion: Based on these findings, the administration of intrathecal morphine clinically reduces the opiate need in the first 96 hours post-operatively.
Source
J Pediatr Rehabil Med
. 2023 Feb 16. doi: 10.3233/PRM-220048. Online ahead of print.
. 2023 Feb 16. doi: 10.3233/PRM-220048. Online ahead of print.
Language
English
URL
10.3233/PRM-220048
Citation
Jared Pennington et al., “Efficacy of intrathecal morphine administration in pediatric patients undergoing selective dorsal rhizotomy,” NEOMED Bibliography Database, accessed April 25, 2024, https://neomed.omeka.net/items/show/12262.