Intracellular Recordings Reveal Integrative Function Of The Basolateral Amygdala In Acoustic Communication

Intracellular Recordings Reveal Integrative Function Of The Basolateral Amygdala In Acoustic Communication

Sergiy Voytenko

Sharad Shanbhag

Jeffrey Wenstrup

Alexander Galazyuk

Journal of Neurophysiology

2023 Apr 26

The amygdala, a brain center of emotional expression, contributes to appropriate behavior responses during acoustic communication. In support of that role, the basolateral amygdala (BLA) analyzes the meaning of vocalizations through integration of multiple acoustic inputs with information from other senses and an animal's internal state. The mechanisms underlying this integration are poorly understood. This study focuses on the integration of vocalization-related inputs to the BLA from auditory centers during this processing. We utilized intracellular recordings of BLA neurons in unanesthetized big brown bats that relies heavily on a complex vocal repertoire during social interactions. Postsynaptic and spiking responses of BLA neurons were recorded to three vocal sequences that are closely related to distinct behaviors (appeasement, low-level aggression, and high-level aggression) and have difference emotional valence. Our novel findings are that most BLA neurons showed postsynaptic responses to one or more vocalizations (31 of 46) but that many fewer neurons showed spiking responses (8 of 46). The spiking responses were more selective than PSP responses. Further, vocal stimuli associated with either positive or negative valence were similarly effective in eliciting EPSPs, IPSPs, and spiking responses. This indicates that BLA neurons process both positive- and negative-valence vocal stimuli. The greater selectivity of spiking responses than PSP responses suggests an integrative role for processing within the BLA to enhance response specificity in acoustic communication.

Voytenko, S., Shanbhag, S., Wenstrup, J., & Galazyuk, A. (2023). Intracellular Recordings Reveal Integrative Function Of The Basolateral Amygdala In Acoustic Communication. Journal of neurophysiology, 10.1152/jn.00103.2023. Advance online publication. https://doi.org/10.1152/jn.00103.2023