Skeletal clues apparently distinguishing Waldenstrom's macroglobulinemia from multiple myeloma and leukemia.

Title

Skeletal clues apparently distinguishing Waldenstrom's macroglobulinemia from multiple myeloma and leukemia.

Creator

Rothschild B M; Ruhli F; Rothschild C

Publisher

American journal of human biology : the official journal of the Human Biology Council

Date

2002
2002-08

Description

This study was conducted to characterize macroscopically and by conventional radiography the bony lesions in a case of Waldenstrom's macroglobulinemia and to compare and contrast it with those of the other major hematologic lymphoproliferative disorders, multiple myeloma and leukemia. Two varieties of lytic skeletal lesions were found in Waldenstrom's macroglobulinemia. One was sharply defined, spheroid lesions with smooth borders and effaced/erased trabeculae. The second was in the form of coalescing pits (holes) with smooth, minimally remodeled edges. The appearance combined features of multiple myeloma and leukemia, but were mutually exclusive in those diseases. Spheroid lesions with effaced edges were absent in leukemia, while pits were absent in multiple myeloma. Fronts of resorption were not noted in Waldenstrom's macroglobulinemia. The combination of some of the features of leukemia and myeloma appear to allow recognition of Waldenstrom's macroglobulinemia.

Subject

Bone and Bones/diagnostic imaging/*pathology; Diagnosis; Differential; Humans; Leukemia/*diagnosis/pathology; Male; Middle Aged; Multiple Myeloma/*diagnosis/pathology; Radiography; Waldenstrom Macroglobulinemia/*diagnosis/pathology

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

532–537

Issue

4

Volume

14

Citation

Rothschild B M; Ruhli F; Rothschild C, “Skeletal clues apparently distinguishing Waldenstrom's macroglobulinemia from multiple myeloma and leukemia.,” NEOMED Bibliography Database, accessed September 28, 2021, https://neomed.omeka.net/items/show/2939.

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