Age- and site-specific decline in insulin-like growth factor-I receptor expression is correlated with differential growth plate activity in the mouse hindlimb.

Age- and site-specific decline in insulin-like growth factor-I receptor expression is correlated with differential growth plate activity in the mouse hindlimb.

Serrat Maria A; Lovejoy C Owen; King Donna

Anatomical record (Hoboken, N.J. : 2007)

2007

2007-04

The proximal and distal growth plates of the principal long bones do not contribute equally to longitudinal growth. Most forelimb elongation occurs at the shoulder and wrist, while most hindlimb growth occurs at the knee. This study examined whether insulin-like growth factor-I (IGF-I), a potent growth regulator, could underlie this variation via differential receptor expression. The spatiotemporal distribution of the IGF-I receptor (IGF-IR) was mapped in hindlimb growth plates (overall and within regional zones) from immature mice using immunohistochemistry. Growth activity was assessed by size/morphology of the growth plate and proliferating cell nuclear antigen (PCNA) expression. Both

Age Factors; Animals; Biological Evolution; Growth Plate/*metabolism/physiology; Hindlimb/*growth & development/metabolism; IGF Type 1/*metabolism; Inbred C57BL; Mice; Proliferating Cell Nuclear Antigen/metabolism; Receptor

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

375–381

4

290