Perineuronal nets in subcortical auditory nuclei of four rodent species with differing hearing ranges.

Title

Perineuronal nets in subcortical auditory nuclei of four rodent species with differing hearing ranges.

Creator

Beebe Nichole L; Schofield Brett R

Publisher

The Journal of comparative neurology

Date

2018
2018-04

Description

Perineuronal nets (PNs) are aggregates of extracellular matrix molecules that surround some neurons in the brain. While PNs occur widely across many cortical areas, subcortical PNs are especially associated with motor and auditory systems. The auditory system has recently been suggested as an ideal model system for studying PNs and their functions. However, descriptions of PNs in subcortical auditory areas vary, and it is unclear whether the variation reflects species differences or differences in staining techniques. Here, we used two staining techniques (one lectin stain and one antibody stain) to examine PN distribution in the subcortical auditory system of four different species: guinea pigs (Cavia porcellus), mice (Mus musculus, CBA/CaJ strain), Long-Evans rats (Rattus norvegicus), and naked mole-rats (Heterocephalus glaber). We found that some auditory nuclei exhibit dramatic differences in PN distribution among species while other nuclei have consistent PN distributions. We also found that PNs exhibit molecular heterogeneity, and can stain with either marker individually or with both. PNs within a given nucleus can be heterogeneous or homogenous in their staining patterns. We compared PN staining across the frequency axes of tonotopically organized nuclei and among species with different hearing ranges. PNs were distributed non-uniformly across some nuclei, but only rarely did this appear related to the tonotopic axis. PNs were prominent in all four species; we found no systematic relationship between the hearing range and the number, staining patterns or distribution of PNs in the auditory nuclei.

Subject

guinea pig; inferior colliculus; mouse; naked mole-rat; plasticity; rat; RRID: AB141637; RRID: AB1500687; RRID: AB2336066; RRID: AB2336874; RRID: AB2336881; RRID: AB90460; superior olive; thalamus

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

972–989

Issue

6

Volume

526

Citation

Beebe Nichole L; Schofield Brett R, “Perineuronal nets in subcortical auditory nuclei of four rodent species with differing hearing ranges.,” NEOMED Bibliography Database, accessed June 17, 2021, https://neomed.omeka.net/items/show/2988.

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