Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees.
Title
Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees.
Creator
Munger Emily L; Edler Melissa K; Hopkins William D; Ely John J; Erwin Joseph M; Perl Daniel P; Mufson Elliott J; Hof Patrick R; Sherwood Chet C; Raghanti Mary Ann
Publisher
The Journal of comparative neurology
Date
2018
2018-12
Description
Astrocytes are the main homeostatic cell of the central nervous system. In addition, astrocytes mediate an inflammatory response when reactive to injury or disease known as astrogliosis. Astrogliosis is marked by an increased expression of glial fibrillary acidic protein (GFAP) and cellular hypertrophy. Some degree of astrogliosis is associated with normal aging and degenerative conditions such as Alzheimer's disease (AD) and other dementing illnesses in humans. The recent observation of pathological markers of AD (amyloid plaques and neurofibrillary tangles) in aged chimpanzee brains provided an opportunity to examine the relationships among aging, AD-type pathology, and astrocyte activation in our closest living relatives. Stereologic methods were used to quantify
Subject
aging; Alzheimer's disease; astrocytes; cerebral cortex; chimpanzees; hippocampus; prefrontal cortex; RRID: AB2109645; RRID: AB223647; RRID: AB2313952; RRID: AB2314223; stereology
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
URL Address
Citation
Munger Emily L; Edler Melissa K; Hopkins William D; Ely John J; Erwin Joseph M; Perl Daniel P; Mufson Elliott J; Hof Patrick R; Sherwood Chet C; Raghanti Mary Ann, “Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees.,” NEOMED Bibliography Database, accessed March 28, 2024, https://neomed.omeka.net/items/show/2991.