Multideterminant role of calcium in hippocampal synaptic plasticity.

Multideterminant role of calcium in hippocampal synaptic plasticity.

Teyler T J; Cavus I; Coussens C; DiScenna P; Grover L; Lee Y P; Little Z

Hippocampus

1994

1994-12

Hippocampal CA1 cells possess several varieties of long-lasting synaptic plasticity: two different forms of long-term potentiation (LTP) and at least one form of long-term depression (LTD). All forms of synaptic plasticity are induced by afferent activation, all involve Ca2+ influx, all can be blocked by Ca2+ chelators, and all activate Ca(2+)-dependent mechanisms. The question arises as how different physiological responses can be initiated by activation of the same second messenger. We consider two hypotheses which could account for these phenomena: voltage-dependent differences in cytosolic Ca2+ concentration acting upon Ca2+ substrates of differing Ca2+ affinities and compartmentalization of the Ca2+ and its substrates.

Animals; Calcium/*physiology; Hippocampus/drug effects/*physiology; Humans; Neuronal Plasticity/drug effects/*physiology; Synapses/drug effects/*physiology

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623–634

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