Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.

Title

Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.

Creator

Frara Nagat; Abdelmagid Samir M; Sondag Gregory R; Moussa Fouad M; Yingling Vanessa R; Owen Thomas A; Popoff Steven N; Barbe Mary F; Safadi Fayez F

Publisher

Journal of cellular physiology

Date

2016
2016-01

Description

Initial identification of osteoactivin (OA)/glycoprotein non-melanoma clone B (gpnmb) was demonstrated in an osteopetrotic rat model, where OA expression was increased threefold in mutant bones, compared to normal. OA mRNA and protein expression increase during active bone regeneration post-fracture, and primary rat osteoblasts show increased OA expression during differentiation in vitro. To further examine OA/gpnmb as an osteoinductive agent, we characterized the skeletal phenotype of transgenic mouse overexpressing OA/gpnmb under the

Subject

Animals; Bone and Bones/*metabolism; Bone Density/physiology; Bone Remodeling/genetics/*physiology; Bone Resorption/metabolism; Cell Differentiation/genetics/*physiology; Eye Proteins/genetics/*metabolism; Membrane Glycoproteins/genetics/*metabolism; Mice; Osteoblasts/*cytology; Osteoclasts/*cytology; Osteogenesis/genetics; Protein-Serine-Threonine Kinases/metabolism; Receptor; Receptors; Transforming Growth Factor beta/metabolism; Transforming Growth Factor-beta Type I; Transgenic

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

72–83

Issue

1

Volume

231

Citation

Frara Nagat; Abdelmagid Samir M; Sondag Gregory R; Moussa Fouad M; Yingling Vanessa R; Owen Thomas A; Popoff Steven N; Barbe Mary F; Safadi Fayez F, “Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.,” NEOMED Bibliography Database, accessed January 21, 2021, https://neomed.omeka.net/items/show/3042.

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