Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.

Title

Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.

Creator

Wehrung Daniel; Sun Shuangyi; Chamsaz Elaheh A; Joy Abraham; Oyewumi Moses O

Publisher

Journal of pharmaceutical sciences

Date

2013
2013-05

Description

Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new class of photoresponsive polymers. The polymers were applied as homopolymer or copolymers of polyethylene glycol (10%, w/w) or polycaprolactone (10%, w/w). APP polymers were comparable to poly(lactic-co-glycolic acid) (PLGA) based on cytotoxicity, macrophage activation, and blood compatibility. Data from biodistribution studies in BALB/c mice showed preferential accumulation in kidney and liver. Meanwhile, potential application of APP polymers as immediate or sustained (implants) drug delivery systems indicated that liver and kidney functions were not distorted. Also, plasma levels of tumor necrosis factor-alpha and interleukin-6 were comparable to PLGA-treated mice (p \textgreater 0.05). A histological analysis of liver and kidney sections showed no detectable damage for APP polymers. The overall data strongly supported potential consideration of APP polymers as photoresponsive delivery systems especially as implantable or tissue-mimicking photopatterned biomaterials.

Subject

Alanine Transaminase/blood; Animals; Biocompatible Materials/chemistry/*metabolism/*toxicity; Cell Line; Creatine/blood; Cytokines/analysis; Erythrocytes/drug effects; Hemolysis/drug effects; Inbred BALB C; Kidney/drug effects/pathology; Light; Liver/drug effects/pathology; Macrophages/cytology/drug effects; Mice; Polycarboxylate Cement/chemistry/*metabolism/*toxicity; Rats; Sprague-Dawley

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1650–1660

Issue

5

Volume

102

Citation

Wehrung Daniel; Sun Shuangyi; Chamsaz Elaheh A; Joy Abraham; Oyewumi Moses O, “Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.,” NEOMED Bibliography Database, accessed June 21, 2021, https://neomed.omeka.net/items/show/3069.

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