Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.

Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.

Wehrung Daniel; Sun Shuangyi; Chamsaz Elaheh A; Joy Abraham; Oyewumi Moses O

Journal of pharmaceutical sciences

2013

2013-05

Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new class of photoresponsive polymers. The polymers were applied as homopolymer or copolymers of polyethylene glycol (10%, w/w) or polycaprolactone (10%, w/w). APP polymers were comparable to poly(lactic-co-glycolic acid) (PLGA) based on cytotoxicity, macrophage activation, and blood compatibility. Data from biodistribution studies in BALB/c mice showed preferential accumulation in kidney and liver. Meanwhile, potential application of APP polymers as immediate or sustained (implants) drug delivery systems indicated that liver and kidney functions were not distorted. Also, plasma levels of tumor necrosis factor-alpha and interleukin-6 were comparable to PLGA-treated mice (p \textgreater 0.05). A histological analysis of liver and kidney sections showed no detectable damage for APP polymers. The overall data strongly supported potential consideration of APP polymers as photoresponsive delivery systems especially as implantable or tissue-mimicking photopatterned biomaterials.

Alanine Transaminase/blood; Animals; Biocompatible Materials/chemistry/*metabolism/*toxicity; Cell Line; Creatine/blood; Cytokines/analysis; Erythrocytes/drug effects; Hemolysis/drug effects; Inbred BALB C; Kidney/drug effects/pathology; Light; Liver/drug effects/pathology; Macrophages/cytology/drug effects; Mice; Polycarboxylate Cement/chemistry/*metabolism/*toxicity; Rats; Sprague-Dawley

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1650–1660

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