Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.

Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.

Mandal Animesh; Bhatia Deepak; Bishayee Anupam

Molecular carcinogenesis

2014

2014-12

Breast cancer represents the second leading cause of cancer-related deaths among women worldwide and preventive therapy could reverse or delay the devastating impact of this disease. Methyl-amooranin (methyl-25-hydroxy-3-oxoolean-12-en-28-oate, AMR-Me), a novel synthetic oleanane triterpenoid, reduced the incidence and burden of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats through antiproliferative and proapoptotic effects. Since chronic inflammation plays an important role in the pathogenesis of breast cancer and several synthetic oleanane compounds are known potent anti-inflammatory agents, we aim to investigate anti-inflammatory mechanisms of

Animals; Anti-Inflammatory Agents/pharmacology; Anticarcinogenic Agents/*pharmacology; Antineoplastic Agents/*pharmacology; Apoptosis/drug effects; Breast Neoplasms/*drug therapy/metabolism; breast tumor; Carcinogenesis/*drug effects; Cell Proliferation/drug effects; Chemoprevention/methods; COX-2; Cyclooxygenase 2/metabolism; DMBA; Down-Regulation/drug effects; Experimental/*drug therapy/metabolism; Female; HSP90; HSP90 Heat-Shock Proteins/metabolism; I-kappa B Proteins/metabolism; inflammation; Inflammation/*drug therapy/metabolism; Mammary Neoplasms; NF-kappa B/metabolism; NF-kappaB; NF-KappaB Inhibitor alpha; oleanane triterpenoid; Oleanolic Acid/*analogs & derivatives/pharmacology; Rats; Sprague-Dawley

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