Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice.

Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice.

Dluzen D E; Gao X; Story G M; Anderson L I; Kucera J; Walro J M

Experimental neurology

2001

2001-07

Deletion of a single copy of the BDNF gene has been shown to affect the nigrostriatal dopaminergic system of young adult BDNF mice. In the present report we evaluated various indices of nigrostriatal dopaminergic function between

Animals; Body Weight/genetics; Brain-Derived Neurotrophic Factor/*deficiency/genetics/*metabolism; Corpus Striatum/*metabolism; Dopamine/*metabolism; Heterozygote; Homozygote; Hypothalamus/metabolism; Methamphetamine/pharmacology; Mice; Motor Activity/drug effects/physiology; Mutant Strains; Norepinephrine/metabolism; Olfactory Bulb/metabolism; Organ Specificity; Substantia Nigra/*metabolism; Walking/physiology

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