Use of brain slices to study long-term potentiation and depression as examples of synaptic plasticity.

Title

Use of brain slices to study long-term potentiation and depression as examples of synaptic plasticity.

Creator

Teyler T J

Publisher

Methods (San Diego, Calif.)

Date

1999
1999-06

Description

Brain slices have been responsible for the majority of advances in our understanding of the cellular aspects of altered synaptic strength underlying memory, long-term potentiation (LTP) and long-term depression (LTD), and increases and decreases, respectively, in synaptic strength at glutamatergic synapses. Our current understanding of LTP and LTD has come largely from studies in hippocampal slices. We consider the strengths and limitations of brain slice technology applied to this subject and conclude that they will continue to have an important role in future studies into the cellular machinery underlying changes in synaptic strength.

Subject

*Long-Term Potentiation; *Neuronal Plasticity; Animals; Brain/*physiology; Electrophysiology/methods; Glutamic Acid/physiology; In Vitro Techniques; Memory/*physiology; Models; Neurological; Synapses/*physiology; Synaptic Transmission

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

109–116

Issue

2

Volume

18

Citation

Teyler T J, “Use of brain slices to study long-term potentiation and depression as examples of synaptic plasticity.,” NEOMED Bibliography Database, accessed April 20, 2021, https://neomed.omeka.net/items/show/3127.

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