The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats.

The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats.

Dluzen D E; Liu B

Journal of neural transmission. General section

1994

1994

In the present experiment we tested the effects of L-DOPA and amphetamine upon dopamine and DOPAC efflux in vitro from superfused corpus striatal tissue fragments of male rats who had been pretreated with reserpine. Male rats were treated with reserpine (5 mg/kg) or its vehicle at 24 hours prior to sacrifice and superfusion of the corpus striatum. Two different modes of L-DOPA (5 microM) and amphetamine (10 microM) stimulation, a brief 10-minute and a continuous

3; 4-Dihydroxyphenylacetic Acid/*metabolism; Amphetamine/*pharmacology; Animals; Cell Compartmentation; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Drug Interactions; Levodopa/*pharmacology; Male; Rats; Research Design; Reserpine/*pharmacology; Secretory Rate/drug effects; Sprague-Dawley

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