Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats.

Title

Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats.

Creator

Schechter M D; Krimmer E C

Publisher

Psychopharmacology

Date

1992
1905-6

Description

Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place preference task. Likewise, the effects of 0.3-1.0 g/kg ethanol on spontaneous locomotor activity over a 30-min period, as well as the loss of righting reflex with a higher ethanol dose (3.0 g/kg), were determined in these animals. The LAS rats reacted more aversively to 1.0 g/kg during conditioned place aversion testing than the HAS animals and also had a shorter mean sleeping time following 3.0 g/kg ethanol. Furthermore, dose-related depression of spontaneous motor activity was seen in the HAS animals and not in the LAS animals over a 30-min period using doses of 0.3, 0.6, or 1.0 g/kg (10% w/v) ethanol. Taken together, the results indicate that the intoxicating sequelae of high ethanol doses, such as ataxia and sedation, may not be correlated with the aversive effects of low ethanol doses.

Subject

Animals; Avoidance Learning/*drug effects; Conditioning; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Motor Activity/drug effects; Operant/drug effects; Rats; Sleep/drug effects; Species Specificity

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

564–568

Issue

4

Volume

107

Citation

Schechter M D; Krimmer E C, “Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats.,” NEOMED Bibliography Database, accessed May 16, 2021, https://neomed.omeka.net/items/show/3151.

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