Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction.

Title

Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction.

Creator

DelloStritto Daniel J; Connell Patrick J; Dick Gregory M; Fancher Ibra S; Klarich Brittany; Fahmy Joseph N; Kang Patrick T; Chen Yeong-Renn; Damron Derek S; Thodeti Charles K; Bratz Ian N

Publisher

Basic research in cardiology

Date

2016
2016-03

Description

We demonstrated previously that TRPV1-dependent coupling of coronary blood flow (CBF) to metabolism is disrupted in diabetes. A critical amount of H2O2 contributes to CBF regulation; however, excessive H2O2 impairs responses. We sought to determine the extent to which differential regulation of TRPV1 by H2O2 modulates CBF and vascular reactivity in diabetes. We used contrast echocardiography to study TRPV1 knockout (V1KO), db/db diabetic, and wild type C57BKS/J (WT) mice. H2O2 dose-dependently increased CBF in WT mice, a response blocked by the TRPV1 antagonist SB366791. H2O2-induced vasodilation was significantly inhibited in db/db and V1KO mice. H2O2 caused robust

Subject

*Coronary Circulation; *Microcirculation; Animals; Capsaicin; Coronary blood flow; Diabetic Angiopathies/*metabolism; HEK293 Cells; Humans; Hydrogen peroxide; Hydrogen Peroxide/*metabolism; Inbred C57BL; Knockout; Male; Mice; Reactive oxygen species; TRPV Cation Channels/*metabolism; TRPV1

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

21–21

Issue

2

Volume

111

Citation

DelloStritto Daniel J; Connell Patrick J; Dick Gregory M; Fancher Ibra S; Klarich Brittany; Fahmy Joseph N; Kang Patrick T; Chen Yeong-Renn; Damron Derek S; Thodeti Charles K; Bratz Ian N, “Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction.,” NEOMED Bibliography Database, accessed August 3, 2021, https://neomed.omeka.net/items/show/3178.

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