Cells in auditory cortex that project to the cochlear nucleus in guinea pigs.

Title

Cells in auditory cortex that project to the cochlear nucleus in guinea pigs.

Creator

Schofield Brett R; Coomes Diana L; Schofield Ryan M

Publisher

Journal of the Association for Research in Otolaryngology : JARO

Date

2006
2006-06

Description

Fluorescent retrograde tracers were used to identify the cells in auditory cortex that project directly to the cochlear nucleus (CN). Following injection of a tracer into the CN, cells were labeled bilaterally in primary auditory cortex and the dorsocaudal auditory field as well as several surrounding fields. On both sides, the cells were limited to layer V. The size of labeled cell bodies varied considerably, suggesting that different cell types may project to the CN. Cells ranging from small to medium in size were present bilaterally, whereas the largest cells were labeled only ipsilaterally. In optimal cases, the extent of dendritic labeling was sufficient to identify the morphologic class. Many cells had an apical dendrite that could be traced to a terminal tuft in layer I. Such "tufted" pyramidal cells were identified both ipsilateral and contralateral to the injected CN. The results suggest that the direct pathway from auditory cortex to the cochlear nucleus is substantial and is likely to play a role in modulating the way the cochlear nucleus processes acoustic stimuli.

Subject

Animals; Auditory Cortex/*cytology; Cochlear Nucleus/*cytology; Fluorescent Dyes; Guinea Pigs; Pyramidal Cells/*cytology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

95–109

Issue

2

Volume

7

Citation

Schofield Brett R; Coomes Diana L; Schofield Ryan M, “Cells in auditory cortex that project to the cochlear nucleus in guinea pigs.,” NEOMED Bibliography Database, accessed May 15, 2021, https://neomed.omeka.net/items/show/3216.

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