Activation of heterotrimeric G-proteins independent of a G-protein coupled receptor and the implications for signal processing.

Activation of heterotrimeric G-proteins independent of a G-protein coupled receptor and the implications for signal processing.

Cismowski M J; Lanier S M

Reviews of physiology, biochemistry and pharmacology

2005

1905-06

Heterotrimeric G-proteins are key transducers for signal transfer from outside the cell, mediating signals emanating from cell-surface G-protein coupled receptors (GPCR). Many, if not all, subtypes of heterotrimeric G-proteins are also regulated by accessory proteins that influence guanine nucleotide binding, guanosine triphosphate (GTP) hydrolysis, or subunit interactions. One subgroup of such accessory proteins (activators of G-protein signaling; AGS proteins) refer to a functionally defined group of proteins that activate selected G-protein signaring systems in the absence of classical G-protein coupled receptors. AGS and related proteins provide unexpected insights into the regulation of the

*Signal Transduction; Animals; Biological; G-Protein-Coupled/*metabolism; Heterotrimeric GTP-Binding Proteins/*metabolism; Humans; Models; Receptors

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

57–80

155