Is mortality due to primary malignant brain and other central nervous system tumors decreasing?

Title

Is mortality due to primary malignant brain and other central nervous system tumors decreasing?

Creator

Gittleman Haley; Kromer Courtney; Ostrom Quinn T; Blanda Rachel; Russell Jeffrey; Kruchko Carol; Barnholtz-Sloan Jill S

Publisher

Journal of neuro-oncology

Date

2017
2017-06

Description

Primary malignant brain and other central nervous system tumors (BT) are a rare cancer that causes morbidity and mortality disproportionate to their incidence. This study presents the most up-to-date mortality data for malignant BT in the United States (US) by histology groupings, age, race, and sex. Mortality rates for malignant BT were generated using the Center for Disease Control's National Vital Statistics Systems (NVSS, \textasciitilde100% of US) data from 1975 to 2012. Histology-specific incidence-based mortality rates were calculated using the National Cancer Institute's Surveillance, Epidemiology, and End-Results 9 (SEER9, \textasciitilde9.4% of US) data from 1975 to 2012. Joinpoint modeling was used to estimate trends. Mortality was similar in both the NVSS and SEER9 datasets. Overall, mortality from 1975 to 2012 was higher among men, higher in older individuals, and higher in Whites compared to other races. Persons age 65+ years had significant increases in mortality for all malignant tumors overall and for glioma histologies, while persons age \textless20 years had no significant changes in mortality. This study reports up-to-date mortality rates by histology groupings, age, race, and sex for malignant BT. There have been no significant changes in overall mortality due to these tumors from 1975 to 2012. There have been significant increases in mortality in the elderly (age 65+ years), especially those age 75-84 years, mirroring the effect of overall population aging. Examining age-, race-, sex-, and histology-specific morality at the population level can provide important information for clinicians, researchers, and public health planning.

Subject

80 and over; Adult; Age Distribution; Age Factors; Aged; Aging; Brain tumors; Centers for Disease Control and Prevention (U.S.)/statistics & numerical data; Central Nervous System Neoplasms/*epidemiology/*mortality; Female; Glioma; Glioma/*epidemiology/*mortality; Humans; Incidence; Incidence-based mortality; Male; Middle Aged; Mortality; National Cancer Institute (U.S.)/statistics & numerical data; Prevalence; Retrospective Studies; Sex Factors; Time trends; United States/epidemiology; Young Adult

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

265–275

Issue

2

Volume

133

Citation

Gittleman Haley; Kromer Courtney; Ostrom Quinn T; Blanda Rachel; Russell Jeffrey; Kruchko Carol; Barnholtz-Sloan Jill S, “Is mortality due to primary malignant brain and other central nervous system tumors decreasing?,” NEOMED Bibliography Database, accessed June 23, 2021, https://neomed.omeka.net/items/show/3243.

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