Estimating the annual frequency of synchronous brain metastasis in the United States 2010-2013: a population-based study.

Title

Estimating the annual frequency of synchronous brain metastasis in the United States 2010-2013: a population-based study.

Creator

Kromer Courtney; Xu Jordan; Ostrom Quinn T; Gittleman Haley; Kruchko Carol; Sawaya Raymond; Barnholtz-Sloan Jill S

Publisher

Journal of neuro-oncology

Date

2017
2017-08

Description

Brain metastases (BM) are one of the most common types of brain tumors and are a relatively common event in the disease process for several high-incidence cancer types, including breast and lung cancers. Historically, information on metastases including BM have not been collected as part of national cancer registration in the US, but BM at time of primary cancer diagnosis (SBM), is now collected by the National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) system. Using data from 18 SEER registries from 2010 to 2013, we assessed the frequency of SBM at time of primary diagnosis in the US by site, histology group, sex, race, age, and insurance status. There were 1,634,954 total primary cancer cases in SEER from 2010 to 2013, 1.7% of which presented with SBM. The cancer type with the highest proportion of SBM was lung cancer (10.8% of cases with SBM), followed by esophageal (1.5%), kidney (1.4%), and melanoma (1.2%). SBM varied by age, sex, race, and insurance status for most histologies. Our results reflect the high proportion of patients who are diagnosed with lung cancer at late stages and present with SBM, in contrast to other common cancers in the US where SBM is less common. Demographic variation in molecular subtype and risk behavior may influence variation in SBM. BM is a relatively common event in late stage cancer and cause significant morbidity and mortality, and assessment of accurate population-based data is critical to estimate total disease burden.

Subject

Adolescent; Adult; Age Distribution; Aged; Brain Neoplasms/*epidemiology/*secondary; Breast Neoplasms/epidemiology/*pathology; Cancer registries; Community Health Planning; Female; Humans; Lung cancer; Lung Neoplasms/epidemiology/*pathology; Male; Metastatic brain tumors; Middle Aged; Retrospective Studies; SEER; United States/epidemiology; Young Adult

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

55–64

Issue

1

Volume

134

Citation

Kromer Courtney; Xu Jordan; Ostrom Quinn T; Gittleman Haley; Kruchko Carol; Sawaya Raymond; Barnholtz-Sloan Jill S, “Estimating the annual frequency of synchronous brain metastasis in the United States 2010-2013: a population-based study.,” NEOMED Bibliography Database, accessed March 3, 2021, https://neomed.omeka.net/items/show/3244.

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