The Role of MicroRNAs and Their Targets in Osteoarthritis.

Title

The Role of MicroRNAs and Their Targets in Osteoarthritis.

Creator

Sondag Gregory R; Haqqi Tariq M

Publisher

Current rheumatology reports

Date

2016
2016-08

Description

Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially expressed in cases of osteoarthritis. Furthermore, several targets of these miRNAs important in disease progression have also been identified. In this review, we focus on microRNA biogenesis, regulation, detection, and quantification with an emphasis on cellular localization and how these concepts may be linked to disease processes such as osteoarthritis. Next, we review the relationships of specific microRNAs to certain features and risk factors associated with osteoarthritis such as inflammation, obesity, autophagy, and cartilage homeostasis. We also identify certain microRNAs that are differentially expressed in osteoarthritis but have unidentified targets and functions in the disease state. Lastly, we identify the potential use of microRNAs for therapeutic purposes and also mention certain remedies that regulate microRNA expression.

Subject

*Cartilage; *Inflammation; *MicroRNA; *Osteoarthritis; *Targets; Articular/*metabolism; Cartilage; Inflammation/genetics/*metabolism; Intracellular Signaling Peptides and Proteins; MicroRNAs/genetics/*metabolism; Osteoarthritis/genetics/*metabolism

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

56–56

Issue

8

Volume

18

Citation

Sondag Gregory R; Haqqi Tariq M, “The Role of MicroRNAs and Their Targets in Osteoarthritis.,” NEOMED Bibliography Database, accessed October 21, 2021, https://neomed.omeka.net/items/show/3263.

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