Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population.

Title

Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population.

Creator

Walton R G; Hudak R; Green-Waite R J

Publisher

Biological psychiatry

Date

1993
1993-07

Description

This study was designed to ascertain whether individuals with mood disorders are particularly vulnerable to adverse effects of aspartame. Although the protocol required the recruitment of 40 patients with unipolar depression and a similar number of individuals without a psychiatric history, the project was halted by the Institutional Review Board after a total of 13 individuals had completed the study because of the severity of reactions within the group of patients with a history of depression. In a crossover design, subjects received aspartame 30 mg/kg/day or placebo for 7 days. Despite the small n, there was a significant difference between aspartame and placebo in number and severity of symptoms for patients with a history of depression, whereas for individuals without such a history there was not. We conclude that individuals with mood disorders are particularly sensitive to this artificial sweetener and its use in this population should be discouraged.

Subject

Adult; Aspartame/*adverse effects/*therapeutic use; Cross-Sectional Studies; Depressive Disorder/diagnosis/*drug therapy/psychology; Double-Blind Method; Eye Diseases/etiology/physiopathology; Female; Headache/etiology; Humans; Male; Middle Aged; Placebos; Psychiatric Status Rating Scales; Vision Disorders/etiology/physiopathology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

13–17

Issue

1

Volume

34

Citation

Walton R G; Hudak R; Green-Waite R J, “Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population.,” NEOMED Bibliography Database, accessed December 7, 2021, https://neomed.omeka.net/items/show/3283.

Social Bookmarking