Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.
Title
Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.
Creator
Carrillo A J; Dluzen D E
Publisher
Brain research
Date
1993
1993-06
Description
This study was designed to determine the influence of the hypothalamus on the content of vasoactive intestinal peptide (VIP) in the anterior pituitary. Disruption of the hypothalamic-pituitary connection was performed by ablating the arcuate-median eminence (ARC-ME) region in adult male rats. Fifteen days later, there was a significant reduction in pituitary mass, adrenal and testicular weight and an increase in water consumption and serum prolactin levels indicating the elimination of hypothalamic influence on the pituitary gland in the ARC-ME group when compared to controls. Anterior pituitary VIP content was also significantly reduced in the lesion group. These data suggest that the hypothalamus is involved in the regulation of pituitary VIP.
Subject
Adrenal Glands/anatomy & histology; Animals; Anterior/*physiology; Arcuate Nucleus of Hypothalamus/*physiology; Drinking Behavior; Hypothalamo-Hypophyseal System/*physiology; Male; Median Eminence/*physiology; Organ Size; Pituitary Gland; Pituitary Gland/anatomy & histology; Prolactin/blood/metabolism; Rats; Sprague-Dawley; Testis/anatomy & histology; Time Factors; Vasoactive Intestinal Peptide/*metabolism
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Carrillo A J; Dluzen D E, “Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.,” NEOMED Bibliography Database, accessed April 19, 2024, https://neomed.omeka.net/items/show/3293.