Conditioned place aversion produced by dopamine release inhibition.

Title

Conditioned place aversion produced by dopamine release inhibition.

Creator

Schechter M D; Meechan S M

Publisher

European journal of pharmacology

Date

1994
1994-08

Description

CGS 10746B, a dopamine release inhibitor with properties similar to the atypical antipsychotic clozapine, was assessed as to its behavioral properties using spontaneous locomotor activity and the conditioned place preference test. Rats conditioned with interperitoneally administered doses of 1.25, 2.5, 5.0, 10.0, 20.0 or 30.0 mg/kg CGS 10746B showed a conditioned place aversion, whereas only doses of 5.0 mg/kg or greater suppressed locomotor activity. Results are discussed in terms of dopaminergic mediation of conditioned place preference and spontaneous locomotor activity and methodological concerns involved in employing the conditioned place preference test with drugs that produce opposing affective cues.

Subject

Analysis of Variance; Animal; Animals; Antipsychotic Agents/administration & dosage/*pharmacology; Aversive Therapy; Conditioning (Psychology); Disease Models; Dopamine Antagonists/administration & dosage/*pharmacology; Dose-Response Relationship; Drug; Injections; Intraperitoneal; Male; Motor Activity/*drug effects; Random Allocation; Rats; Sprague-Dawley; Thiazepines/administration & dosage/*pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

133–137

Issue

2

Volume

260

Citation

Schechter M D; Meechan S M, “Conditioned place aversion produced by dopamine release inhibition.,” NEOMED Bibliography Database, accessed May 18, 2021, https://neomed.omeka.net/items/show/3299.

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