Genetic selection for nicotine activity in mice correlates with conditioned place preference.

Title

Genetic selection for nicotine activity in mice correlates with conditioned place preference.

Creator

Schechter M D; Meehan S M; Schechter J B

Publisher

European journal of pharmacology

Date

1995
1995-06

Description

Genetically heterogenous stock (HS) mice are being used to develop lines which have differential locomotor response to subcutaneously administered (0.75 mg/kg) nicotine. These groups of nicotine-depressed, nicotine-activated or randomly bred control mice were tested as to conditioned place preference using the same dose of nicotine employed to determine their locomotor performance in activity tests. Results indicate that the nicotine-activated mice showed a significantly greater preference to nicotine when compared to the nicotine-depressed mice; this effect was seen in the first generation and continued in the more recently tested third generation. Evidence is offered to support the hypothesis that it is the stimulatory effects of drugs (of abuse) that can be directly correlatable with the strength of their reinforcing effect upon behavior.

Subject

*Conditioning; Analysis of Variance; Animals; Female; Inbred Strains; Male; Mice; Movement/*drug effects; Nicotine/*pharmacology; Operant

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

59–64

Issue

1

Volume

279

Citation

Schechter M D; Meehan S M; Schechter J B, “Genetic selection for nicotine activity in mice correlates with conditioned place preference.,” NEOMED Bibliography Database, accessed September 25, 2021, https://neomed.omeka.net/items/show/3302.

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