The aromatic amino acid decarboxylase inhibitor, NSD-1015, increases release of dopamine: response characteristics.

Title

The aromatic amino acid decarboxylase inhibitor, NSD-1015, increases release of dopamine: response characteristics.

Creator

Dluzen D; Reddy A; McDermott J

Publisher

Neuropharmacology

Date

1992
1992-12

Description

Addition of the aromatic amino acid decarboxylase inhibitor, NSD-1015 (10 microM), to Krebs'-Ringer phosphate (KRP) superfusion medium, significantly increased the release of dopamine in vitro from superfused corpus striatum tissue fragments of male rats. A dose-dependent increase in release of dopamine was obtained in response to increasing concentrations of NSD-1015, with 1.0 microM being the minimally effective dose. In addition to the striatum, NSD-1015 also increased the release of dopamine from superfused hypothalamic tissue fragments. This capacity of NSD-1015 to increase release of dopamine was calcium-independent, appeared to be somewhat specific and could apparently increase the release of dopamine in vivo, as indicated by increases in the release of the metabolite of dopamine, DOPAC, under conditions of push-pull perfusion. Although the putative role of NSD-1015 is as an aromatic amino acid decarboxylase inhibitor, the present results demonstrate that, either as a result of this function and/or in addition to this role, NSD-1015 is a potent activator of the release of dopamine.

Subject

*Aromatic Amino Acid Decarboxylase Inhibitors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Brain/*drug effects/metabolism; Dopamine/*metabolism; Hydrazines/*pharmacology; Male; Rats; Sprague-Dawley

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1223–1229

Issue

12

Volume

31

Citation

Dluzen D; Reddy A; McDermott J, “The aromatic amino acid decarboxylase inhibitor, NSD-1015, increases release of dopamine: response characteristics.,” NEOMED Bibliography Database, accessed May 14, 2021, https://neomed.omeka.net/items/show/3308.

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